Abstract: The benefits of agricultural innovations in increasing productivity and reducing postharvest losses have not been shared universally. Postharvest losses of horticultural crops are high in low- and middle-income countries (LMICs) where small-scale farms play a critical role in production. A number of innovations in application of the cold chain and the dry chain to address postharvest losses are appropriate for small-scale enterprises. Case studies offer additional insights about some of these technologies, including how they made an impact for small-scale farms. Increasing global food insecurity demands could be mitigated by rapid and sustainable changes in postharvest management in LMICs. Relatively recent attention on food loss and waste (FLW) among key global organizations offers an opportunity for greater levels of resources being dedicated to this urgent issue. Major production-side global initiatives have achieved systemic impacts across LMICs. A more coordinated effort among researchers and other stakeholders working to reduce postharvest losses is needed to achieve significant reductions in LMICs.